一、科研项目

2008年又新增科研项目21项，其中国家级6项，具体如下。

二、科研经费

由表1计算出的新增科研项目经费为285.5万元，到帐经费420.13万元，主要用于科研中小型设备费、材料费、测试化验加工费、燃料费、会议差旅费、国际合作交流费以及文献/出版和劳务费。

三、获奖成果和专利

陈波教授指导的硕士论文《生物样品中硫普罗宁等药物的分析方法研究》获得湖南省优秀硕士学位论文。

张友玉教授指导的硕士论文《电化学石英晶体阻抗及现场红外光谱电化学在生物和聚合物体系中的研究应用》获得湖南省优秀硕士学位论文。

蒋雁峰老师《中国酒文化》多媒体课件获湖南师范大学第三届教师课件大赛一等奖；

蒋雁峰老师《中国酒文化》多媒体课件获湖南省高等学校第八届“中南杯”多媒体教育软件大赛二等奖。

四、获批专利4项。

五、发表的论文

2008年重点实验室发表的论文共106篇，其中SCI收录论文41篇，影响因子4以上的明显上升，尤其在Anal. Chem., J. Phys. Chem. B, Organ. Lett., J. Organ. Chem. Biosens. Bioelectron., Electrochem. Commun.，Catal. Lett. 等杂志上发表论文数量明显增加。发表论文如下：

1. Cao Z., Jiang X.,Xie Q. and Yao S., A third-generation hydrogen peroxide biosensor based on horseradish peroxidase immobilized in a tetrathiafulvalene- tetracyanoquinodimethane/multiwalled carbon nanotubes film,Biosensors & Bioelectronics, 2008,24, 222-227.

2. Chen D.-W., Xie Q.-J., Jiang X.-Q. and Yao S.-Z., Interactions of quercetin with casein and bovine serum albumin as well as effects of coexisting carbon nanotubes,Acta Physico-Chimica Sinica, 2008,24, 379-387.

3. Deng Y., Huang W., Chen X. andLi Z., Facile fabrication of nanoporous gold film electrodes,Electrochemistry Communications, 2008,10, 810-813.

4. Fu Y., Chen C.,Xie Q., Xu X., Zou C., Zhou Q., Tan L., Tang H., Zhang Y. and Yao S., Immobilization of enzymes through one-pot chemical preoxidation and electropolymerization of dithiols in enzyme-containing aqueous suspensions to develop biosensors with improved performance,Analytical Chemistry, 2008,80, 5829-5838.

5. Huang M.-Z., Li H.-W., Pang H.-L., Zhang Q., Ren Y.-G. andYin D.-L., Synthesis and herbicidal activity of N- 2,4-disubstituted-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tet rahydropyrimidin-1-yl)phenyl imides,Chinese Journal of Organic Chemistry, 2008,28, 1433-1438.

6. Huang X.-C., Liu Y. L., Liang Y., Pi S.-F., Wang F. andLi J.-H., Cycloaddition of arynes with iodonium ylides: a mild and general route for the synthesis of benzofuran derivatives,Organic Letters, 2008,10, 1525-1528.

7. Huang Y., Huang J.,Xie Q.and Yao S., Carbohydrate-protein interactions,Progress in Chemistry, 2008,20, 942-950.

8. Huang Z., Xiao S., Luo D.,Chen B. and Yao S., Simultaneous determination of sibutramine and N-di-desmethylsibutramine in dietary supplements for weight control by HPLC-ESI-MS,Journal of Chromatographic Science, 2008,46, 707-711.

9. Jia X., Tan L., Me Q.,Zhang Y. and Yao S., Quartz crystal microbalance and electrochemical cytosensing on a chitosan/multiwalled carbon nanotubes/Au electrode,Sensors and Actuators B-Chemical, 2008,134, 273-280.

10. Jiang X., Cao Z., Liu T.,Xie Q. and Yao S., Electrochemical quartz crystal microbalance studies on the codeposition of dextran sodium sulfate with the charge-transfer complexes generated during electrooxidation of benzidine derivatives,Electroanalysis, 2008,20, 976-983.

11. Jiang X., Cao Z., Tang H., Tan L.,Xie Q. and Yao S., Electrochemical surface plasmon resonance studies on the deposition of the charge-transfer complex from electrooxidation of o-tolidine and effects of dermatan sulfate,Electrochemistry Communications, 2008,10, 1235-1237.

12. Jiang X.-Q., Cao Z.-J.,Xie Q.-J. and Yao S.-Z., Electrodeposition of the charge-transfer complex generated during electrooxidation of o-tolidine and the effects of coexisting chondroitin sulfate,Acta Physico-Chimica Sinica, 2008,24, 230-236.

13. Li Y.-F., Yu L., He Z. andHe H.-Y., Synthesis, characterization and catalytic behavior of bihetero-atom Ti-V-beta zeolite,Chinese Journal of Inorganic Chemistry, 2008,24, 117-123.

14. Liang Y., Tao L.-M., Zhang Y.-H. andLi J.-H., Palladium-Catalyzed Cross-Coupling Reactions of 1,2-Diiodoalkenes with Terminal Alkynes: Selective Synthesis of Unsymmetrical Buta-1,3-diynes and 2-Ethynylbenzofurans,Synthesis-Stuttgart, 2008, 3988-3994.

15. Liu M.-L., Luo J.,Zhang Y.-Y.and Yao S.-Z., In Situ Piezoelectric Infrared Spectroelectrochemistry for Study of Electrochemical Oxidation of o-Tolidine,Chinese Journal of Analytical Chemistry, 2008,36, 1172-1176.

16. Ma J., Peng X., Cheng K.-W., Chen F., Yang D.,Chen B. and Wang M., Use of capillary electrophoresis to evaluate protective effects of methylglyoxal scavengers on the activity of creatine kinase,Journal of Separation Science, 2008,31, 2846-2851.

17. Peng X., Cheng K.-W., Ma J.,Chen B., Ho C.-T., Lo C., Chen F. and Wang M., Cinnamon bark proanthocyanidins as reactive carbonyl scavengers to prevent the formation of advanced glycation endproducts,Journal of Agricultural and Food Chemistry, 2008,56, 1907-1911.

18. Qi A., Li M. andMao L., Application of single drop microextraction in the determination of phthalate esters and parabens in drugs by gas chromatography-mass spectrometry,Se pu = Chinese journal of chromatography / Zhongguo hua xue hui, 2008,26, 306-309.

19. Su Y., Xie Q., Chen C., Zhang Q.,Ma M. and Yao S., Electrochemical quartz crystal microbalance studies on enzymatic specific activity and direct electrochemistry of immobilized glucose oxidase in the presence of sodium dodecyl benzene sulfonate and multiwalled carbon nanotubes,Biotechnology Progress, 2008,24, 262-272.

20. Tan L., Jia X. e., Jiang X., Zhang Y., Tang H., Yao S. andXie Q., Real-time monitoring of the cell agglutination process with a quartz crystal microbalance,Analytical Biochemistry, 2008,383, 130-136.

21. Tan Y., Xie Q., Huang J., Chen D., Chen X., Tu X., Li Y.,Ge B. and Yao S., Electrochemical quartz crystal microbalance study on the two-electrode-system cyclic voltammetric behavior of Prussian blue films,Science in China Series B-Chemistry, 2008,51, 1074-1086.

22. Tan Y.,Xie Q., Huang J., Duan W., Ma M. and Yao S., Study on glucose biofuel cells using an electrochemical noise device,Electroanalysis, 2008,20, 1599-1606.

23. Tang B.-X., Guo S.-M., Zhang M.-B. andLi J.-H., N-arylations of nitrogen-containing heterocycles with aryl and heteroaryl halides using a copper(I) oxide nanoparticle/1,10-phenanthroline catalytic system,Synthesis-Stuttgart, 2008, 1707-1716.

24. Tang B.-X., Tang D.-J., Tang S., Yu Q.-F., Zhang Y.-H.,Liang Y., Zhong P. and Li J.-H., Selective synthesis of spiro 4,5 trienyl acetates via an intramolecular electrophilic ipso-lodocyclization process,Organic Letters, 2008,10, 1063-1066.

25. Tang B.-X., Yin Q., Tang R.-Y. andLi J.-H., Electrophilic ipso-Cyclization of N-(p-Methoxyaryl)propiolamides Involving an Electrophile-Exchange Process,Journal of Organic Chemistry, 2008,73, 9008-9011.

26. Tang S., Peng P., Pi S.-F., Liang Y., Wang N.-X. andLi J.-H., Sequential intermolecular aminopalladation/ortho-arene C-H activation reactions of N-phenylpropiolamides with phthalimide,Organic Letters, 2008,10, 1179-1182.

27. Tang S., Peng P., Zhong P. andLi J.-H., Palladium-catalyzed C-H functionalization of N-arylpropiolamides with aryliodonium salts: Selective synthesis of 3-(1-arylmethylene)oxindoles,Journal of Organic Chemistry, 2008,73, 5476-5480.

28. Tu X.,Xie Q., Huang Z., Jia X. e. and Ye M., Electrocatalytic oxidation and sensitive determination of L-cysteine at a poly(aminoquinone)-carbon nanotubes hybrid film modified glassy carbon electrode,Microchimica Acta, 2008,162, 219-225.

29. Wang G., Yu N., Peng L., Tan R., Zhao H., Yin D., Qiu H., Fu Z. andYin D., Immobilized chloroferrate ionic liquid: An efficient and reusable catalyst for synthesis of diphenylmethane and its derivatives,Catalysis Letters, 2008,123, 252-258.

30. Wang J.,Chen B. and Yao S., Analysis of six synthetic adulterants in herbal weight-reducing dietary supplements by LC electrospray ionization-MS,Food Additives and Contaminants Part a-Chemistry Analysis Control Exposure & Risk Assessment, 2008,25, 822-830.

31. Wang J., Wang L.-P., Yang D.-J. andChen B., A new method for safety monitoring of natural dietary supplements--quality profile,Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2008,42, 489-493.

32. Wang Q., Tang H., Xie Q., Jia X.,Zhang Y., Tan L. and Yao S., The preparation and characterization of poly(o-phenylenediamine)/gold nanoparticles interface for immunoassay by surface plasmon resonance and electrochemistry,Colloids and Surfaces B-Biointerfaces, 2008,63, 254-261.

33. Xia Y., Yin D., Rong C., Xu Q., Yin D. andLiu S., Impact of Lewis acids on Diels-Alder reaction reactivity: A conceptual density functional theory study,Journal of Physical Chemistry A, 2008,112, 9970-9977.

34. Xiao Y., Huang H., Yin D., Guo D., Mao L. andFu Z., Oxidation of anethole with hydrogen peroxide catalyzed by oxovanadium aromatic carboxylate complexes,Catalysis Communications, 2008,10, 29-32.

35. Xiao Z.-W., Li Y.-F., He Z., Yu L. andHe H.-Y., Amphiphilic Ti-V-beta Zeolites: Preparation and Phase-boundary Catalysis,Chinese Journal of Inorganic Chemistry, 2008,24, 1880-1884.

36. Xie Y.-X., Wang J., Li J.-H. andLiang Y., Reusable and Ligand-Free Palladium-Catalyzed Suzuki-Miyaura Cross-Couplings of Aryl Halides with Arylboronic Acids in Tetra-n-butylammonium Bromide,Chinese Journal of Chemistry, 2008,26, 2261-2266.

37. Xu Q., Yang Z.,Yin D. and Zhang F., Synthesis of chalcones catalyzed by a novel solid sulfonic acid from bamboo,Catalysis Communications, 2008,9, 1579-1582.

38. Yu Q.-F., Zhang Y.-H., Yin Q., Tang B.-X., Tang R.-Y., Zhong P. andLi J.-H., Electrophilic ipso-iodocyclization of N-(4-methylphenyl)propiolamides: Selective synthesis of 8-methyleneazaspiro 4,5 trienes,Journal of Organic Chemistry, 2008,73, 3658-3661.

39. Zhang Z., Zhang C., Su X., Ma M.,Chen B. and Yao S., Carrier-mediated liquid phase microextraction coupled with high performance liquid chromatography for determination of illicit drugs in human urine,Analytica Chimica Acta, 2008,621, 185-192.

40. Zhong S., Fu Z., Tan Y.,Xie Q., Xie F., Zhou X., Ye Z., Peng G. and Yin D., 5-chloro-7-iodo-8-quinolinolatomanganese(III) with the feature of pH-regulated molecular switches as a highly efficient catalyst for epoxidation of olefins with hydrogen peroxide,Advanced Synthesis & Catalysis, 2008,350, 802-806.

41. Zhong S., Tan Y., Fu Z., Me Q., Xie F., Zhou X., Ye Z., Peng G. andYin D., A highly efficient method of epoxidation of olefins with hydrogen peroxide catalyzed by changeable hexadentate 8-quinolinolato manganese(III) complexes,Journal of Catalysis, 2008,256, 154-158.

六、人才引进和研究生培养

队伍建设和人才培养呈现出良好的发展态势，2008年新进博士1名，新晋教授1人，副教授3人，讲师1人。培养博士毕业研究生4人，硕士毕业研究生74人。新招收博士7人，硕士80人。

七、国内外学术交流和会议

2008年学术氛围异常活跃，共邀请国内外知名教授来院来室作学术报告和学术交流，美国刘育教授（南开）, 井上佳久教授(日本), 李灿（中国科学院），刘述斌教授、Urban 教授（美国），栗莉、陈小如博士（美国）等教授来院讲学和交流。

八、依托单位给予的支持

学校按照教育部重点实验室建设要求和管理条例，在人力、物力和财力方面对“化学生物学及中药分析”重点实验室给予全力支持,学校每年20万元的运行经费。

九、运行经费的使用情况

2006年学校拨运行经费20万，主要用于开放基金、学术委员会开支，仪器设备费、材料与资料费、会议差旅费、维修费、学术交流、复印与打印等方面。

另外，通过重点学科和湖南省拨给姚院士的经费，投入实验室购置仪器设备，具体如下:

七、开放基金

本实验室已设立开放基金，2007年已批14项，经费外拨已办理。2008年又有11项申请。

八、其他

2008年5月，承办国家基金委主办的“中药分析化学战略研讨会”。