本课题组秉承“理想合成”的科学理念。致力于金属促进的碳碳键、碳氢键及碳杂原子键的切断和构建的研究。发现价键切断和构建的规律和机制，发展高效的、选择性的和绿色的有机合成方法，实现有用物质的理想合成。

目前研究工作主要集中在下面三个方面：

1. 利用无机硫源构建有机含硫化合物；

2. 利用芳炔构建各种芳香化合物；

3. 发展过渡金属催化的交叉偶联-串联反应策略。

课题组负责人：梁云，博士，教授，博士生导师

课题组主要科学研究基金项目：

1. 国家自然科学基金面上项目：基于无机硫源的偶联-串联反应合成硫杂环化合物研究（21572051，在研）

2. 国家自然科学基金面上项目：基于芳炔与碘叶立德反应及其应用的研究(21072054，结题)。

3. 教育部科学技术项目：基于芳炔与羧酸酯的反应及其在有机合成中应用研究（213027A，在研）。

4. 教育部博士点基金：基于邻三甲基硅芳基三氟磺酸酯为芳炔的前体与碘叶立德反应的研究（20094306120003，结题）。

5. 湖南省自然科学基金重点项目：基于芳炔与羧酸酯的反应及其在有机合成中应用研究（213027A，结题）。

6. 湖南省教育厅科学研究基金重点项目：基于芳炔与羧酸酯的反应及其在有机合成中应用研究(12A095，结题)；

7. 湖南省教育厅科学研究基金重点项目：基于无机硫盐的双硫化反应合成硫醚和硫杂环化合物的研究15A109，在研）；

8. 湖南师范大学青年优秀人才基金：基于芳炔与碘叶立德反应及其应用的研究（ET21003，结题）。

9. 北京分子科学国家实验室基金：基于1,1-偕二卤-1,4-共轭二卤化合物多反应位点的交叉偶联-串联反应研究（结题）。

课题组主要论文发表：

1. Dang, P.; Zeng, W.;Liang, Y.^* Copper-Catalyzed Three-Component Synthesis of Benzothiazolethiones from o?Iodoanilines, Isocyanide, and Potassium Sulfide, Org. Lett. 2015, 17, 34-37.

2. Yang, Y.; Huang, H.; Liu, W.; Liang, Y.^* Dual Role of Alkynyl Bromides in One-Step Synthesis of Bromo-Substituted Alkynyl Sulfides, Synth. Commun. 2015, 45, 86-93.

3. Zhang, X.; Zeng, W.; Yang, Y.; Huang, H.; Liang, Y.*, Copper-catalyzed double C−S bonds formation via different paths: synthesis of benzothiazoles from N-benzyl-2-iodoaniline and potassium sulfide, Org. Lett. 2014, 16, 876-879.

4. Yang, Y.; Zhang, X.; Zeng, W.; Huang, H.; Liang, Y.*, Copper catalyzed three-component synthesis of benzothiazolones from o-iodoanilines, DMF, and potassium sulfide, RSC Adv. 2014, 4, 6090-6093.

5. Yang,Y.; Huang,H.; Wu, L.; Liang, Y.^* Palladium-catalyzed annulation of benzynes with N-substituted-N-(2-halophenyl)formamides: synthesis of phenanthridinones, Org. Biomol. Chem. 2014, 12, 5351-5355.

6. Zeng, W.; Dang, P.; Zhang, X.; Liang Y. ^*; Peng, C. Copper-catalyzed synthesis of 2-aminobenzothiazoles from carbodiimide and sodium hydrosulfide, RSC Adv. 2014, 4, 31003-31006.

7. Wu, L.; Huang, H.; Liang, Y.^*; Cheng, Pi. Regio- and Stereoselective Synthesis of 2?Amino-dienes via Decarboxylative Amination of 4?(Ethoxycarbonyl)-2,3-allenols by TsNCO, J. Org. Chem. 2014, 79, 11264-11269.

8. Huang, H.; Yang, Y.; Zhang, X.; Zeng, W.; Liang, Y.*,Transition-metal-free approach to synthesis of indulines from N-(ortho-chloromethyl)aryl amides and iodonium ylides, Tetrahedron Lett. 2013, 54, 6049-6052.

9. Yang, Y.; Huang, H.; Zhang, X.; Zeng, W.; Liang, Y.*,Synthesis of 2-alkynyltetrahydrofuran derivatives from tetrahydrofuran and alkynyl bromides, Synthesis 2013, 3137-3146.

10. Zhang, X.; Zeng, W.; Yang, Y.; Huang, H.; Liang, Y.*,Transition-metal-free method for the synthesis of benzo[b]thiophenes from o-halovinylbenzenes and K₂S via direct S_NAr-type reaction, cyclization, and dehydrogenation process, Synlett. 2013, 24, 1687-1692.

11. Liang, Y.; Geng, W.; Wei, J.; Xi, Z.*Palladium-Catalyzed Intermolecular Coupling of 2-Silylaryl Bromides withAlkynes: Synthesis of Benzosiloles and Heteroarene-Fused Siloles by Catalytic Cleavage of the C(sp3)-Si Bond, Angew. Chem. Int. Ed. 2012,51, 1934.

12. Yang, Y.; Zhang, X.; Liang, Y.* Copper-catalyzed coupling of 1,2-dibromo-1-styrenes with sulfonamides for the preparation of ynamides, Tetrahedron Lett.2012, 53, 6557-6560.

13. Zhang, X.; Yang, Y.; Liang, Y.*Palladium-catalyzed double N-arylation to synthesize multisubstituted dibenzoazepine derivatives, Tetrahedron Lett. 2012, 53, 6406-6408.

14. 张晓昀，杨源，梁云*，利用无机硫源构建含硫杂环化合物的研究，第八届有机化学学术会议论文集，66页，2013.10.17-20，重庆，邀请报告。

15. Liang, Y.; Geng, W.; Wei, J.; Ouyang, K.; Xi, Z.* Palladium-catalyzedsilyl C(sp³)-H bond activation, Org. Biomol. Chem.2012, 10,1537-1542.

16. Liang, Y.; Zhang, S.; Xi, Z.* Palladium-Catalyzed Synthesis of Benzosilolo[2,3-b]indoles via Cleavage of a C(sp³)-Si Bond and Consequent Intramolecular C(sp²)-Si Coupling, J, Am,Chem, Soc. 2011, 133, 9204.

17. Liang, Y.; Meng, T.; Zhang, H.; Xi, Z.*Palladium-catalyzed, one-pot, three-component approach to a-alkynylindoles from o-bromo-(2,2-dibromovinyl)benzenes, terminal alkynes and arylamines, Synlett. 2011, 911.

18. Pi, S.-F.; Yang, X.-H.; Huang, X.-C.; Liang, Y.*; Yang, G.-N.; Zhang, X.-H.; Li,J.-H.* Palladium-Catalyzed Cyclocarbonylation of Arynes with Methyl Allyl Carbonates: Selective Synthesis of 1H-Inden-1-ones, J.Org. Chem, 2010, 75, 3484.

19. Li, R.-J.; Pi, S.-F.; Liang, Y.*; Wang, Z.-Q.; Song, R.-J.;Chen, G.-X.; Li, J.-H.* Palladium-catalyzed annulations of arynes with 2-(2-iodophenoxy)-1-substituted ethanones Chem.Commun., 2010, 8183.

20. Liu, Y.-L.; Liang, Y.;* Pi, S.-F.; Li, J.-H.*, Selective Synthesis of o-Acylbenzylphosphonates by Insertion Reactions of Arynes into β-Ketophosphonates, J.Org. Chem, 2009, 74, 5691.

21. Pi, S.-F.; Tang, B.-X.; Yin, D.-L.; Li, J.-H.*; Liu, Y.-L.; Liang,Y.*, Palladium-Catalyzed Decarboxylative Coupling of Allylic Alkynoates with Arynes, Org. Lett., 2009, 11,2309.

22. Liu, Y.-L.; Liang, Y.;* Pi, S.-F.; Huang, X.-C.; Li,J.-H.*, Palladium-Catalyzed Cocyclotrimerization of Allenes with Arynes: Selective Synthesis of Phenanthrenes, J. Org. Chem, 2009, 74,3199.

23. Huang, X.-C.; Wang, F.; Liang, Y.;* Li, J.-H.*, Halopalladation/Decarboxylation/Carbon-Carbon Forming Domino Process: Synthesis of 5-Halo-6-substituted Benzo[b]naphtho[2,1-d]furans, Org. Lett., 2009, 11, 1139.

24. Huang, X.-C.; Liu, Y.-L.; Liang, Y.;* Pi, S.-F.; Wang, F.; Li, J.-H.*,Cycloaddition of Arynes with Iodonium Ylides: A Mild and General Route for the Synthesis of Benzofuran Derivatives, Org. Lett. 2008, 10, 1525.

25. Xie, Y.-X.; Wang, J.; Li, J.-H.*; Liang, Y.*, Reusable and Ligand-Free Palladium-Catalyzed Suzuki-Miyaura Cross-Couplings of Aryl Halides with Arylboronic Acids in Tetra-n-butylammonium Bromide, Chinese Journal of Chemistry, 2008, 26, 2261.